Cost of Resource Essay Example for Free

Cost of Resource Essay The allocation and cost of resources need to be carefully monitored if a project is to be delivered on-time and on-budget. At a minimum this section will contain the following: Allocation of resources to project tasks (both labor and material) Cost estimates for project resources Gantt diagram showing duration estimates for all tasks and their sequencing (including precedence relations) and highlighting any critical path(s) arising from task dependencies ultimately determining the minimal duration of a project In addition summarize any relevant facts about the project duration, number or type of resources, critical task sequencing, or how duration estimates were arrived at, and any financial implications (for example, budget or cost reports of the project as well) Develop a baseline for your project plan so that all future variances are captured. Write 3 to 4 pages on your findings. When it comes to succeeding in college, there are many influential factors. In fact, even your choice of seat can make a difference. Try to score a seat near the front of the lecture hall rather than one right next to the exit. You are more likely to stay engaged and can ask your professor questions easily.

Mercedes M class Essay Example for Free

Mercedes M class Essay This year Mercedes-Benz Company announcing the new M Class SUVs for their middle aged costumers. The M Class offers a stylish alternative to box-on-box SUVs, and can be equipped with as much off-road capability as most drivers would ever need. It doesn’t go light on luxury or amenities, either, and its cabin feels more like a Mercedes sedan than a premium sport-use. In fact, Mercedes has made an effort to step up its materials, fit and finish game on the inside of third-generation M Class models, and its efforts show. Market segmentation strategy The purpose for segmenting a market is to allow your marketing/sales program to focus on the subset of prospects that are most likely to purchase your offering. There are four different dimensions used to describe a product’s market segmentation. These four things are demographic, behavioral, psychographic, and geographic. The most popular marketing segmentation used by researchers is the demographic segmentation. Demographic segmentation: Mercedes Benz M class demographic includes adults, both male and female, mostly middle-aged people. They are not very popular with youngsters since the brand is very expensive. Yes there is college kids and in some cases even high school kids with Mercedes Benz cars, but they were still purchased by their parents. Due to their relative expense, * 2013 Mercedes-Benz M class /http://www.caranddriver.com/news/2013-mercedes-benz-gl-class-photos-and-info-news The M class is targeted to people of middle to high incomes. Unlike Chrysler or GMC, for instance, Mercedes doesn’t offer prices ranging from high to low so the products don’t resemble consumers with a low income. Behavioral segmentation: is the most powerful approach because it uses actual consumer behavior or product usage to make distinctions among market segments. When referring to the M class behavioral segmentation, it is purchased among heavy users, it’s a car you can use on a day-to-day basis, whether going to work or to the grocery store. Most of the people that purchase the M class do it for different reasons; quality, beauty, speed, etc. Psychographic segmentation: the M class is commonly purchased among  people who have a family, since it’s a SUV. Some of the reasons its customers prefer the M class is for its safety, and by being a luxury car it gives you a certain status among society. When referring to the geographic segmentation of the M class, it is mainly targeted toward somewhat wealthy countries. The M class is sold worldwide m even though its biggest market is in the United States. Other target markets for the M class may include single males, females, single parents with or without children or teenagers, married couples, and males and females who are divorced. There are many different target markets for the M class and the ones mentioned before are its main target markets. Positioning: Mercedes Benz has always been known for delivering quality, reliability and its safety. Delivering Mercedes-brand qualities and features at a more moderate price is a luxury marketing strategy conceived with a long range vision. Their goal is to build lifetime brand loyalty by meeting the automobile consumer at nearly every price point throughout their progress through different life stages. In line with the Mercedes-Benz brand philosophy, the new Mercedes-Benz M-Class represents the embodiment of the Mercedes-Benz holistic safety concept of Real Life Safety, which is derived from what happens in a real accident situation. In combination with the front and rear deformation zones, the high-strength passenger cell of the M-Class provides a highly effective foundation for the occupant protection systems. Both active safety and driver-fitness safety in the new M-Class are further improved by assistance systems that will already be familiar, primarily from the S-Class and E-Class. Reference: 1. Benz says its like a three-row S-class, but theres also a heck of a lot of M-class. / http://www.leftlanenews.com/new-car-buying/mercedes-benz/m-class/review/ 2. Mercedes Benz M class /http://www.caranddriver.com/news/2013-mercedes-benz-gl-class-photos-and-info-news/ 3. On Mercedes Benz’ luxury /http://www.smallbusinessadvocate.com/small-business-articles/on-mercedes-benz-luxury-1111/

Emerging Therapies for the Treatment of MS

Emerging Therapies for the Treatment of MS Currently, there are six new drugs that are being assessed by clinical scientists and some of these drugs have entered or completed phase 2 level and phase 3 level clinical trials. Three of these drugs are oral drugs and they include Lanquinimod, Teriflumomide and Di-methyl fumarate. The other three are monoclonal antibodies (mAb) namely Alemtuzumab, Daclizumab and Rituximab (Borrero et al, 2012). All of these drugs target the immune system in different ways but some of them still present with some side effects as well which are discussed below. Starting with Lanquinimod, it is an immunomodulator that is currently being trialled in patients with RRMS and SPMS. It has a very small recommended dose of 0.6 mg daily and it exhibits anti-inflammatory properties. These properties are believed to support the downregulation of MHC class II transcription factors, stimulation of neurotrophic factors, activation and up-regulation of the IL-4 pathway in CD4+ T cell for anti-inflammatory effects. It also promotes apoptosis in Cytotoxic T-cells (CD8+) and B-cells and also suppresses metabolism in CD14+ and natural killer cells (Thà ¶ne et al., 2016). It is currently undergoing Phase III trials and has resulted in 23% reduction in the rate of relapse of MS while there has been a 37% reduction in contrast enhancing lesions in volunteers (Borrero et al, 2012). Its side effect is only the upregulation of Liver Function Tests (LFTs) The second oral drug that is undergoing phase III clinical trials is Teriflunomide and it is being trialled for patients with RRMS and SPMS. Doses ranging from 7 to 14 mgs daily are recommended to be administered orally in patients. Its mode of action depends on sequestering the production of DNA pyrimidine bases by acting as an inhibitor for the enzyme dihydroorotate dehydrogenase, which is essential in de novo pyrimidine synthesis in T and B cells that are rapidly dividing. This reduces any inflammation that wouldve been caused by those cells and thus immune suppression is achieved. According to Borrero et al, it has a success rate of 61% in reducing contrast enhancing lesions, a rate of 30% in reducing Annualized relapse rates (ARRs) and disability progression was observed to be reduced to 23-30%. Terfilunomidess side effects include Nasopharyngitis; which is the inflammation of the nasopharyngeal duct, diarrhoea, back pain, fatigue, hair thinning, influenza, Urinary Tract Infecti on (UTI), nausea and elevated LFTs (Borrero et al, 2012). The third oral drug is Di-methyl fumarate (DMF) or BG-12. It is also undergoing type III clinical trials for patients with RRMS. Its suggested dose is 120-24 mg three times a day. It has shown a decrease of 69% in contrast enhancing lesions in its phase II trial and its phase III trials have so far showed 53% reduction in ARR, 38% reduction in disability progression and in 2 years, by 49% (Borrero et al, 2012). Di-methyl fumarates mode of action is still being debated but it is believed that it can regulate oxidative pathways which may in turn affect other signalling pathways that are responsible for inducing tissue damage. Studies by Moharregh -Khiabani et al in 2009 showed that DMF had an inhibitory effect on the nuclear factor NFÃŽ ºB dependant, TNF ÃŽ ± induced gene transcription in endothelial cells. It is also believed that DMF can stimulate cells to secrete cytokines such as IL-10, IL-4 and IL_5 which have anti-inflammatory properties thus allowing a more Th2 focused response than a Th1 one (Wierinckx et al., 2005). Moreover, DMF is believed to have a neuroprotective therapeutic effect as well. This occurs as it causes an upregulation in the levels of the detoxification enzyme; NADPH but like other emerging drugs, it has side effects. These side effects include diarrhoea, cramps, elevated LFT, nausea and can cause flushing and in very rare cases, Progressive multifocal leukoencephalopathy (PML) (MS Society 2016). Other novel therapies include the use of monoclonal antibodies (mAb) for the treatment of MS. As of now, there are three that are undergoing phase II and III trials respectively. Alemtuzumab is one such mAb that is in its phase III clinical trial for patients with RRMS and SPMS. Its recommended dosage is Intravenous infusion of 12- 24 mg daily for a course of 5 days every month if its a 1 year course and this can be increased to 24mg on the 12th month. Its mode of action is causing the destruction of circulating immune cells by binding on to CD52 on mature leukocytes which results in the lysis of CD4+ and CD8+ T cells, B cells, eosinophils, NK cells, monocytes and macrophages as well (Hart and Bainbridge 2016). In phase III trials, it has so far shown up to 75% reduction in sustained accumulation disability and up to 74% reduction in relapse rate but has been associated with potentially increasing the risk of autoimmunity which included thyroiditis, idiopathic thrombocytopenic purpur a, autoimmune thyroid-related problems, Goodpastures syndrome and also, can cause flushing and headaches (Borrero et al, 2012) . As of yet, it has not been approved by the FDA as it is still undergoing trials but it is used as a medication for treating a form of blood cancer called B-cell chronic lymphocytic leukaemia (B-CLL) (FDA 2016). References https://www.researchgate.net/profile/Anne_Wierinckx/publication/7750124_Detoxication_enzyme_inducers_modify_cytokine_production_in_rat_mixed_glial_cells/links/0c960534be656953a2000000/Detoxication-enzyme-inducers-modify-cytokine-production-in-rat-mixed-glial-cells.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724664/ http://journals.sagepub.com/doi/pdf/10.1177/1756285612450936 https://www.fda.gov/Drugs/DrugSafety/ucm082681.htm http://www.ajmc.com/journals/supplement/2016/cost-effectiveness-multiple-sclerosis/cost-effectiveness-multiple-sclerosis-current-emerging-treatment/P-3 https://www.mssociety.org.uk/what-is-ms/treatments-and-therapies/licensed-disease-modifying-drugs/Tecfidera

Shirley Jacksons The Lottery :: The Lottery by Shirley Jackson

  Ã‚  Ã‚  Ã‚  Ã‚  Why would a civilized and peaceful town would ever suggest the horrifying acts of violence can take place anywhere at anytime and the most ordinary people can commit them. Jackson's fiction is noted for exploring incongruities in everyday life, and â€Å"The Lottery†, perhaps her most exemplary work in this respect, examines humanity's capacity for evil within a contemporary, familiar, American setting. Noting that the story’s characters, physical environment, and even its climactic action lacks significant individuating detail, most critics view â€Å"The Lottery.† As a modern-day parable or fable, which obliquely addresses a variety of themes, including the dark side of human nature, the danger of ritualized behavior, and the potential for cruelty when the individual submits to the mass will. Shirley Jackson also addresses cruelty by the citizen’s refusal to stand up and oppose â€Å"The Lottery.† Violence and cruelty is a majo r theme in â€Å"The Lottery.† The theme in â€Å"The Lottery† is violence and cruelty. Violence and cruelty is a major theme because there is a lot of violence and cruelty in the world. The Lottery has been read as addressing such issues as the public's fascination with salacious and scandalizing journalism, McCarthyism, and the complicity of the general public in the victimization of minority groups, epitomized by the Holocaust of World War II. The Holocaust was very cruel and violent cause other people didn’t like certain people so they just kill them and their children and still now we have violence and cruelty with wars and people that hate each other.   Ã‚  Ã‚  Ã‚  Ã‚  On the morning of June 27 of a recent year, the 300 villagers of an American village prepare for the annual lottery in a mood of excitement. The horrible tradition of the lottery is so old that some of its ritual has been forgotten and some has been changed. Its basic purpose is entirely unremembered, but residents are present to take part in it. The children in the village created a â€Å"great pile of stones† in one corner of the stoning square. The civic-minded Mr. Summers has been sworn in and then he hands a piece of paper to the head of each family. When it is discovered the Hutchinson family has drawn the marked slip, each member of the family Bill, Tessie, and the children is given another slip. Silence prevails as suspense hovers over the proceedings. After helplessly protesting the unfairness of the first drawing, Tessie finds that she holds the marked slip.

A Journey into Darkness in Heart of Darkness Essay -- Heart Darkness e

A Journey into Darkness in Heart of Darkness      Ã‚  Ã‚   Joseph Conrad, in his story, "Heart of Darkness," tells the tale of two mens' realization of the dark and evil side of themselves. Marlow, the "second" narrator of the framed narrative, embarked upon a spiritual adventure on which he witnessed firsthand the wicked potential in everyone.   On his journey into the dark, forbidden Congo, Marlow encountered Kurtz, a "remarkable man" and "universal genius," who had made himself a god in the eyes of the natives over whom he had an imperceptible power.   These two men were, in a sense, images of each other:   Marlow was what Kurtz may have been, and Kurtz was what Marlow may have become.      Ã‚  Ã‚  Ã‚   Like a jewel, "Heart of Darkness" has many facets.   From one view it is an exposure of Belgian methods in the Congo, which at least for a good part of the way sticks closely to Conrad's own experience.   Typically, however, the adventure is related to a larger view of human affairs. Marlow told the story one evening on a yacht in the Thames estuary as darkness fell, reminding his audience that exploitation of one group by another was not new in history.   They were anchored in the river, where ships went out to darkest Africa.   Yet, as lately as Roman times, London's own river led, like the Congo, into a barbarous hinterland where the Romans went to make their profits.   Soon darkness fell over London, while the ships that bore "civilization" to remote parts appeared out of the dark, carrying darkness with them, different only in kind to the darkness they encounter.      Ã‚  Ã‚  Ã‚   These thoughts and feelings were merely part of the tale, for Co... ...ntempt to be a kind of moral heroism.       Works Cited Adelman, Gary. Heart of Darkness: Search for the Unconscious. Boston: Little & Brown, 1987. Bradley, Candice. "Africa and Africans in Conrad's Heart of Darkness." (24 Jan. 1996). Online Internet. 3 October 1998. Available: http://www.lawrence.edu/~johnson/heart. Conrad, Joseph. Heart of Darkness. Ed. Robert Kimbrough. 17th ed. New York: Norton, 1988. Levenson, Michael. "The Value of Facts in the Heart of Darkness." Nineteenth-Century Fiction 40 (1985):351-80. Rosmarin, Adena. "Darkening the Reader: Reader Response Criticism and Heart of Darkness." Joseph Conrad Heart of Darkness: A Case Study in Contemporary Criticism. Ed. Ross C. Murfin. New York: St. Martin's, 1989. Watt, Ian. Conrad in the Nineteenth Century. San Diego: U. of California P, 1979. 168-200, 249-53.   

What Happened Next in Rip Van Winkle ? :: Rip Van Winkle Essays

What Happened Next in Rip Van Winkle ? Rip Van Winkle acquired a belief the day he fell asleep---July 3, 1766, say---a belief that that day was a fine day. He held this belief under the character ``Today [the day of this thought] is nice.'' Then he slept for twenty years and two days, until July 5, 1786, and walked back to town.   What happened next? The possibility that struck Kaplan and Evans is that Rip merely updated his belief. On July 3rd he never forms any explicit belief other than ``Today [the day of this thought] is a nice day''. When he awakes on July 5th, the belief is updated, due to his awareness of having slept through a night, and his lack of awareness of having slept twenty additinal years, to ``Yesterday [the day before the day of this thought] was a nice day.'' He falls out of epsitemic contact with the current day when he falls asleep, but has a ready-made character in mind for when he wakes up. But then what is there left of the original belief except the false one about July 4th? But the false belief can not be the true belief, so hasn't Rip lost the belief in question? This seems to be the argument that threatened Kaplan and appealed to Evans. But even in the case of such thin updating, there are backup characters for Rip to hold his belief under. When Rip believes, towards evening, as it grows dark, ``Today [the day of this thought] was a nice day,'' he has memories of seeing the flowers and feeling the sun, and so forth. So the character, ``That day [the day I remember] is or was a nice day'' is available to sustain his belief, when the attempt at updating goes awry. Even if these memories fade, there is the character, ``That day [the day this belief was acquired] is or was a nice day.'' So my view is this. When he awakes on July 5th, Rip updates his belief according to his view of how the context has changed. His view about the change of context is mistaken, and the new character, ``Yesterday [the day before the day of this thought] was nice'' is not a way of believing the original content. But that is no reason to say that Rip has lost his original belief.

Benjamin Franklin Essay

Benjamin Franklin is a notable figure in American history and perhaps one of the most recognizable in name and appearance. Franklin was one of the most important people during the early years of the nation because of his involvement with the Declaration of Independence and the diplomatic and political advances he made during his life as a citizen of the new United States of America. Known for his curious mind, Franklin is also remembered for his many scientific contributions to the field of Physics. While many people would say that George Washington is the father of this country, there is a good argument that Benjamin Franklin should hold the title in the history books. Why? Because he is the only founding father to have signed the Declaration of Independence, the Treaty of Paris, and the Constitution, and it is these three documents as a whole that created the United States as its own nation apart from Great Britain and established its place in the world. Without his ability to be diplomat, his political sense, and his scientific advancements, the United States would have likely never become the nation that it is today and for this reason, Franklin is destined to have a place in American history. Benjamin Franklin was, for all intents and purposes, first and foremost a shrewd and successful politician. During his political life he accomplished a great deal of important things. One of the most notable of Franklin’s political dealings was his absolute disapproval of the Stamp Act and he was at the head of the effort to have it repealed by Parliament. He was appointed by the Continental Congress to the committee that would draft the Declaration of Independence and was in fact the person that edited it. In his later years, he was part of the committee that created the United States’ Constitution and was single-handedly able to help the unhappy delegates come to a compromise and helped, through an impassioned speech, get them to sign it. In his last years he was also known for being a dedicated abolitionist and spent a great deal of political energy asserting this cause. Throughout his life, his writings and activism helped establish the United States as an American nation. In fact, he is credited with having inventing the idea of an American nation. As a diplomat, Benjamin Franklin was well-liked and received by other nations because of his friendly nature, his intelligent conversation, and his ability to connect with people on a different level. His most notable diplomatic accomplishment was the Treaty of Paris, which helped establish the United States as a separate and equal nation. Franklin was well-liked by the French because he was able to quickly understand the customs of the people and used his ability to negotiate over the dinner table to effectively make connections with the French. Throughout his life, Franklin would be known as an accomplished diplomat for the United States. As a scientist, Franklin’s accomplishments are well known by Americans. Franklin was an inventor who enjoyed trying out new ideas and coming up with new scientific ideas. Among his inventions were the lightening rod, the glass harmonica, and bifocal glasses. His experiments with electricity were among his most well-known and became important contributions to Physics. He also founded the American Philosophical Society, where men of science would get together and discuss their inventions and scientific research. Throughout his life, his greatest love would be science and his study of electricity. Benjamin Franklin is perhaps the most important of the founding fathers because his contributions to the country went far beyond simply serving as president or fighting in a war. Franklin was able to use his ability to work with others, be diplomatic, and his intelligence to help create the nation that he envisioned. He not only helped the United States break away from England, but was there to help the American people gain status in the world at large and to help create the Constitution that would be the foundation of American society. His accomplishments in science and his founding of the American Philosophical Society helped bring science and culture to a fledgling nation that was trying to find its own way. For this he will always be remembered as the Father of the country. Bibliography â€Å"Benjamin Franklin. † Wikipedia. 29 Jan. 2007 .